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0% (P<0.01) and 39.2% (P<0.01), respectively; amitriptyline treatment significantly increased the number of Ki67+cells and DCX+ cells in the DG by 43.8% (P<0.01) and 46.7% (P<0.01), respectively, as compared with WKY rats. ② When compared with control group, WKY rats showed a significant decrease in sucrose preference (P<0.01), less total horizontal distance (P<0.01) and less time entered the center field (P<0.01) in the OFT, the immobility time in the FST was increased significantly (P<0.01). Amitriptyline treatment significantly impr