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We searched PubMed, EMBASE, Cochrane Library, online of Science and the ClinicalTrials.gov with key words (Mesenchymal stem cells [MSCs], Knee osteoarthritis, Effectiveness and protection), after which performed a systematic review and cumulative metaanalysis of all RCTs and retrospective relative studies. To evaluate the effectiveness and safety of MSC in knee OA therapy, we applied aesthetic analog scale score, Western Ontario and McMaster Universities Osteo-arthritis Index and unfavorable events. We inclu
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