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der and younger age are significant predictors associated with TP. © 2020 Chang et al.Background Abnormal RGS4 gene expression may cause neurotransmitter disorders, resulting in schizophrenia. The association between RGS4 and the risk of schizophrenia is controversial, and there has been little research on the SNPs in the promoter region of RGS4. Purpose The present study was performed to detect the association between SNPs in the promoter region of the RGS4 gene and the risk of schizophrenia. Materials and Methods In this study, the 175