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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first choice of ADHD drugs, have the most research behind them, and they are quick-acting. However, they aren't for everyone. These drugs increase the communication between nerves and areas in the brain, thereby reducing symptoms of ADHD. These medications can also cause side-effects like a change in heart rate or blood pressure, as well as an increase in appetite. are the most common medications used to treat A