https://www.selleckchem.com/pr....oducts/retatrutide.h
All target compounds significantly inhibited hTS enzyme activity and demonstrated significant antitumor activity against five cancer cell lines. Notably, 7 had a high selectivity index (SI) and unique inhibitory effects on eight NSCLC cells. In-depth research indicated that 7 could induce apoptosis by the mitochondrial pathway in A549 and PC-9 cells through the upregulation of wild-type P53 protein expression. Additionally, 7 was shown to inhibit angiogenesis and . studies, compared to PTX, 7 significantly inhibited tumor growth in
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