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ClinicalTrials.gov, identifier [NCT03889457].Objective This meta-analysis comprehensively evaluated the association between ABO blood group and the risk of preeclampsia (PE). Design Systematic review and meta-analysis. Data sources PubMed, Web of Science, and ScienceDirect databases from their inception to September 23, 2020. Methods Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were obtained through random-effects and fixed-effects models according to heterogeneity. Meta-regression analysis was applied to explore the sour