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Aberrations of monocyte/macrophage-associated cytokines are increasingly recognized in systemic lupus erythematosus (SLE). However, the combined expression of these cytokines has not been sufficiently studied in relation to either disease activity or renal involvement in SLE. Here, we explored clinical values of monocyte/macrophage-associated cytokines for monitoring of disease activity and renal involvement in SLE patients. A total of 44 healthy people and 100 SLE patients were enrolled in this study. The serum levels of