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This analysis allows also to state important hypothesis that in general case for formation of clathrate III crystals presence of special guest molecules occupying several cages (or special ions in the host lattice) is necessary. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.The bacterium Vibrio cholerae is a natural inhabitant of aquatic ecosystems across the planet. V. cholerae serogroups O1 and O139 are responsible for cholera outbreaks in developing countries accounting for 3-5 million infections worldwide and 28.800-130.000 d