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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first-choice ADHD treatment, because they're the most studied and have the fastest-acting effects. But they aren't right for everyone. These medications increase the signaling between nerves and regions in the brain to reduce symptoms of ADHD. These medications can also cause side-effects like a change in heart rate or blood pressure, as well as the loss of appetite. Stimulants Stimulants are among the most commonly u