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The proposed bootstrap framework offers a systematic approach to reduce the number of trials required to estimate the evoked response. The general validity of our findings is neither bound to any particular type of MEG/EEG data nor to any specific source localization method. Practical implications of this work relate to the optimization of acquisition time of MEG/EEG experiments, thus reducing stress for the subjects (especially for patients) and minimizing related artifacts. Practical implications of this work relate to the optimization of acquisit